Magnetically activated and guided isotope separation

textThis dissertation describes a proof-of-principle experiment demonstrating a technique for stable isotope enrichment called Magnetically Activated and Guided Isotope Separation (MAGIS) (1). Over the past century a large number of enriched isotopes have become available, thanks largely to electromagnetic separators called calutrons that were developed during World War II. These isotopes have found applications across an array of fields including medicine, basic science, and energy. Due to substantial maintenance and operating costs, the United States decommissioned the last of its calutrons in 1998, leading to demand for alternative methods of isotope separation. Our experiment suggests the promise for MAGIS as a viable alternative for replenishing stockpiles previously provided by calutrons. Our apparatus combines optical pumping with a scalable magnetic field gradient to enrich lithium-7 (Li-7) by suppressing lithium-6 (Li-6) throughput in a lithium atomic beam. We first evaporate lithium metal in a crucible in order to generate thermal, high flux beam. We then perform optical pumping on Li-6 atoms, magnetically polarizing a substantial fraction of Li-6 atoms into the entirely high-field seeking 2²S₁/₂, F = 1/2 ground state. The resultant beam then samples a magnetic field gradient produced by a 1.5 m long array of rare-earth permanent magnets bent over its length by 20 mrad. This geometry prevents high-field seeking lithium atoms from reaching the plane beyond the magnets, while efficiently deflecting low-field seeking atoms. We measured Li-6 suppression – using independent techniques – along the plane after the magnets beyond a factor of 200, corresponding to Li-7 enrichment to better than 99.95%. As apparatus-specific hindrances appeared to limit this suppression, we believe that we should achieve better enrichment on a commercial apparatus. We also measured both the absolute flux beyond the single, 1.5 in tall magnet array and the efficiency for guiding feedstock material to the collection plane. Given the planar configuration for the field gradient, the flux that we measured should scale linearly with both magnet height and the number of arrays surrounding the source. Our measurements therefore indicate that – at source temperatures that we actually investigated – a commercial apparatus fitting within a volume of just several cubic meters should yield hundreds of grams of enriched (to beyond 99.95%) Li-7 per year. In addition, we observed a competitive ratio between collected material and feedstock with greater than 20% of lithium incident upon the magnet array reaching beyond the magnets. Benchmarking our work against the calutron, we demonstrated comparable enrichment in a manner that should scale to the production of similar quantities. In contrast, however, MAGIS should require vastly less energy input. While calutrons required massive currents for maintaining a static magnetic field over a substantial area, the only non-shared energy expense for MAGIS is the cost for running the low power lasers for optical pumping. Via additional analysis, we have supplemented this proof-of-principle experiment with schemes for applying MAGIS to over half of the stable isotopes in the periodic table. Due to the success of this demonstration and the broad applicability of the principles, we believe that MAGIS will play an important role in the future of stable isotope enrichment.Physic

Lessons Learned from Development of a Software Tool to Support Academic Advising

We detail some lessons learned while designing and testing a decision-theoretic advising support tool for undergraduates at a large state university. Between 2009 and 2011 we conducted two surveys of over 500 students in multiple majors and colleges. These surveys asked students detailed questions about their preferences concerning course selection, advising, and career paths. We present data from this study which may be helpful for faculty and staff who advise undergraduate students. We find that advising support software tools can augment the student-advisor relationship, particularly in terms of course planning, but cannot and should not replace in-person advising.Comment: 5 Figures, revised version including more figures and cross-referencin

Morphological discrimination of granular materials by measurement of pixel intensity distribution

The paper provides statistical analysis of the photographs of four various granular materials (peas, pellets, triticale, wood chips). For analysis, the (parametric) ANOVA and the (nonparametric) Kruskal-Wallis tests were applied. Additionally, the (parametric) two-sample t-test and (non-parametric) Wilcoxon Rank-Sum Test for pairwise comparisons were performed. In each case, the Bonferroni correction was used. The analysis shows a statistical evidence of the presence of differences between the respective average discrete pixel intensity distributions (PID), induced by the histograms in each group of photos, which cannot be explained only by the existing differences among single granules of different materials. The proposed approach may contribute to the development of a fast inspection method for comparison and discrimination of granular materials differing from the reference material, in the production process

Phantom-based quality assurance of a clinical dose accumulation technique used in an online adaptive radiation therapy platform

PURPOSE: This study aimed to develop a routine quality assurance method for a dose accumulation technique provided by a radiation therapy platform for online treatment adaptation. METHODS AND MATERIALS: Two commonly used phantoms were selected for the dose accumulation QA: Electron density and anthropomorphic pelvis. On a computed tomography (CT) scan of the electron density phantom, 1 target (gross tumor volume [GTV]; insert at 6 o\u27clock), a subvolume within this target, and 7 organs at risk (OARs; other inserts) were contoured in the treatment planning system (TPS). Two adaptation sessions were performed in which the GTV was recontoured, first at 7 o\u27clock and then at 5 o\u27clock. The accumulated dose was exported from the TPS after delivery. Deformable vector fields were also exported to manually accumulate doses for comparison. For the pelvis phantom, synthetic Gaussian deformations were applied to the planning CT image to simulate organ changes. Two single-fraction adaptive plans were created based on the deformed planning CT and cone beam CT images acquired onboard the radiation therapy platform. A manual dose accumulation was performed after delivery using the exported deformable vector fields for comparison with the system-generated result. RESULTS: All plans were successfully delivered, and the accumulated dose was both manually calculated and derived from the TPS. For the electron density phantom, the average mean dose differences in the GTV, boost volume, and OARs 1 to 7 were 0.0%, -0.2%, 92.0%, 78.4%, 1.8%, 1.9%, 0.0%, 0.0%, and 2.3%, respectively, between the manually summed and platform-accumulated doses. The gamma passing rates for the 3-dimensional dose comparison between the manually generated and TPS-provided dose accumulations were \u3e99% for both phantoms. CONCLUSIONS: This study demonstrated agreement between manually obtained and TPS-generated accumulated doses in terms of both mean structure doses and local 3-dimensional dose distributions. Large disagreements were observed for OAR1 and OAR2 defined on the electron density phantom due to OARs having lower deformation priority over the target in addition to artificially large changes in position induced for these structures fraction-by-fraction. The tests applied in this study to a commercial platform provide a straightforward approach toward the development of routine quality assurance of dose accumulation in online adaptation

Efficient singlet oxygen photogeneration by zinc porphyrin-dimers upon one- and two-photon excitation

Funding: UK EPSRC (EP/L017008/1), IDWS acknowledges a Royal Society Wolfson Research Merit Award. This work is a part of the ITN-EJD-2017 project POLYTHEA which has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 764837.The development of photodynamic therapy at depth requires photosensitizers which have both sufficient quantum yield for singlet oxygen generation and strong two photon absorption. Here we show that this can be achieved by conjugated linkage of zinc porphyrins to make dimers. We determined the quantum yield of generation of 1O2, φΔ , by measuring emission at 1270 nm using a near infra-red streak camera and found it to increase from 15% for a single porphyrin unit to 27 47% for the dimers with a conjugated linker. Then, we measured the spectra of two-photon absorption cross section, σ2, by a focus-tunable Z scan method, which allows for nondestructive investigation of light-sensitive materials. We observed a strong enhancement of the two photon absorption coefficient in the dimers, especially those with an alkyne linker. These results lead to an excellent figure of merit for two photon production of singlet oxygen (expressed by the product σ2xφΔ) in the porphyrin dimers, of around 3700 GM, which is very promising for applications involving treatment of deep tumors by photodynamic therapy.PostprintPeer reviewe

Chiral soliton models, large N_c consistency and the Theta^+ exotic baryon

Predictions for a light collective $\Theta^+$ baryon state (with strangeness +1) based on the collective quantization of chiral soliton models are shown to be inconsistent with large $N_c$ QCD. The lightest strangeness +1 state to emerge from the analysis has an excitation energy which at large $N_c$ scales as $N_c^0$ while collective quantization is legitimate only for excitations which go to zero as $N_c \to \infty$. This inconsistency strongly suggests that predictions for $\Theta^+$ properties based on collective quantization of chiral solitons are not valid.Comment: 5 pages, 1 figure. This is the version to be published; minor typos have been corrected and a reference adde